Spokane Naturopathic Medicine | Doctor Lindsay Donahue
October 19th, 2017
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Statin drugs & Beta-blockers deplete CoQ10

Feb2008 Reports Coenzymeq 05big

CoQ10 (Coenzyme Q10) is found naturally in the human body and has a ubiquitous presence; that’s where it gets its alternative name, ubiquinone. CoQ10’s primary action is within the mitochrondrial electron-transport chain and the synthesis of ATP. Rephrased and simplified. . . CoQ10 plays a large role in cellular energy production. CoQ10 is an antioxidant which scavenges free radicals.

Despite the fact we make CoQ10 in our cells, there are situations where the body isn’t able to meet sufficient CoQ10 demands; this deficiency is most apparent in high metabolic cells, including the: heart, brain, immune system, gingiva, and gastric mucosa.

CoQ10 levels in human organs peak at 20 years of age, except in the pancreas and adrenals where it peaks at 1 year. Once the peak level is achieved, levels continuously decline with age. After the age of 35 to 40 humans begin to lose their ability to synthesize CoQ10.

Low levels of CoQ10 were noted in: cardiovascular disease, hypertension, periodontal disease, asthma, Parkinson disease, and AIDs. CoQ10 supplementation can be beneficial in: Breast Cancer, Muscular Dystrophy, Cardiac disease, Cardiomyopathy, gastric ulcers, Diabetes mellitus, Infertility, and protection during cardiac surgery.

Cholesterol lowering Statin drugs (lovastatin, pravastatin) inhibit the enzyme which is required for biosynthesis for both cholesterol and CoQ10. Studies show Statin drugs compromise CoQ10 synthesis. Beta-blockers propranolol and metoprolol have been shown to inhibit CoQ10 dependent enzymes as well, often contributing to fatigue. There is a potential drug interaction with warfarin since CoQ10 is structurally related to vitamin K2 (menaquinone) and may have procoagulant effects (increases the ability for the blood to clot), INR should be closely monitored if CoQ10 and warfarin are used together.